To conduct analyses of a Canadian population-based case-control dataset to evaluate:
Over the past several decades, incidence rates of non-Hodgkin’s lymphoma (NHL) have been increasing in countries worldwide, including in Canada. Although the reasons for this increase are not clearly understood, lymphomas, multiple myeloma, and soft-tissues sarcomas have been associated with farming and some specific farm exposures. A Canadian population-based case-control study in six provinces was designed to evaluate specific agricultural exposures that might be involved (McDuffie et al., 2001; Pahwa et al., 2006). This important study found a number of interesting associations including links between NHL and the pesticides dicamba, mecoprop, malathion, carbaryl, and 2,4-D (McDuffie et al., 2001). This dataset was used for further analyses in this study.
The dataset was analyzed using logistic regression to evaluate the associations of interest. In addition to information on pesticide use, the study also obtained information on demographic factors, medical history, family history of cancer, lifetime job history, occupational exposure to pesticides, use of personal protective equipment, and tobacco use that was included in the models to control for possible confounding.
The findings of this project contributed to our understanding of the role that agricultural exposures and other factors play in the development of NHL, Hodgkin lymphoma, multiple myeloma, and soft tissue sarcoma — cancers that have been linked to farming in the past. These new analyses provided further information on the carcinogenicity of pesticides, which has relevance for both occupational and non-occupational settings.
In addition, researchers from the U.S. National Cancer Institute and the OCRC have joined the CCSPH dataset with three other datasets of similar case-control studies that were conducted in four American states during the 1980s. More information about this initiative, called the North American Pooled Project, can be found here.
Exposures to multiple pesticides and the risk of Hodgkin lymphoma in Canadian men
Multiple pesticide exposures and the risk of multiple myeloma in Canadian men
Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in Canadian men in six provinces
McDuffie HH, Pahwa P, McLaughlin JR, Spinelli JJ, Fincham S, Dosman JA, Robson D, Skinnider LF, and Choi NW. Non-Hodgkin’s lymphoma and specific pesticide exposures in men: Cross-Canada study of pesticides and health. Cancer Epidemiol Biomarkers Prev 2001; 10: 1155-1163.
Pahwa P, McDuffie HH, Dosman JA, McLaughlin JR, Spinelli JJ, Robson D, Fincham S. Hodgkin lymphoma, multiple myeloma, soft tissue sarcomas, insect repellents, and phenoxyherbicides. J Occup Environ Med 2006; 48: 264-274.