Pahwa P, Karunanayake CP, Dosman JA, Spinelli JJ, McLaughlin JR, Cross-Canada Group. Soft-tissue sarcoma and pesticides exposure in men: Results of a Canadian case-control study. Journal of Occupational and Environmental Medicine 2011;53(11):1279-1286.
OBJECTIVES: The objective was to investigate the putative associations of specific pesticides with soft-tissue sarcoma (STS).
METHODS: A Canadian population-based case-control study conducted in six provinces was used in this analysis. The study design consisted of two stages: a self-administered postal questionnaire and a telephone interview for those reporting pesticides exposure of 10 hours per year or more; and a 15% random sample of the remainder. Conditional logistic regression was used to fit the statistical models.
RESULTS: A positive history of cancer among first-degree relatives and exposure to aldrin and diazinon were statistically significant independent predictors of an increased risk for STS, whereas diagnosis of whopping cough lowered the risk of STS.
CONCLUSIONS: The incidence of STS was associated with specific insecticides after adjustment for other independent predictors.